Komekbay Zh.E., Kaliev A.R., Azbergenov N.K., Gasimov E., Rzayev F.
Komekbay Zh.E., Kaliev A.R., Azbergenov N.K., Gasimov E., Rzayev F.. Cardiac Metastasis from Gastric Cancer: A Clinical Case. Ǵylym aliansy. 2025;2(3):107-115.
Abstract. Cardiac metastasis (CM) is significantly more common than primary cardiac tumors, with autopsy data showing a prevalence of 2.3% to 18.3%, which is 20-40 times higher than that of primary cardiac neoplasms. In patients with widespread metastatic disease, cardiac involvement is observed in 14.2% of cases. However, metastasis to the heart from gastric cancer remains a rare phenomenon.
This report presents a clinical case of metastatic involvement of all cardiac layers (epicardium, myocardium, and endocardium) in a 53-year-old woman with undifferentiated signet-ring cell gastric carcinoma. Comprehensive clinical and postmortem investigations revealed multiple metastases to the lymph nodes, liver, adrenal glands, pancreas, and heart. Histological analysis confirmed tumor infiltration by signet-ring cells, microthrombosis, myolysis, and cardiomyocyte dystrophy. Immunohistochemistry demonstrated CK-positive expression.
This case highlights the importance of oncological vigilance in patients presenting with new cardiac symptoms and underscores the need for early diagnosis using echocardiography, IHC, and a multidisciplinary approach.
Keywords: meteorological factor, atmospheric monitoring, ozone, air pollution, magnetic waves, internet radiation, carcinogens, weather impact, human health
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Komekbay Zh.E. - https://orcid.org/0000-0002-1075-5680
Kaliev A.R. - https://orcid.org/0000-0003-4192-0025
Azbergenov N.K. - https://orcid.org/0009-0001-6328-3883
Gasimov E. - https://orcid.org/0000-0002-5104-4260
Rzayev F. - https://orcid.org/0000-0002-8128-1101
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